KEB-64117 Bioorganic Chemistry, 5 cr
Suitable for postgraduate studies.
Nuno Rafael Candeias, Alexandre Efimov
Nuno Rafael Candeias
|Attend the laboratorial sessions, prepare a short report on the lab works.
Pass the final exam based on the lectures contents and material provided.
Understand and predict the structure and reactivity of principal organic compounds found in biological systems. Learn about the main methods used for synthetic preparation and modification of carbohydrates, amino acids and peptides, nucleic acids and the use of enzymes in asymmetric organic synthesis. The course will be composed by lectures, exercises and weekly laboratory works (2-4 h/session). Upon finalizing the lab works, students will have to prepare a 4 page report that will be used for assessment of the final grade.
|Content||Core content||Complementary knowledge||Specialist knowledge|
|1.||Carbohydrates||classification and nomenclature; reactions of monosaccharides; natural compounds from carbohydrates||anomeric effect; artificial sweeteners|
|2.||amino acids, peptides and proteins||synthesis and reactions of amino acids; reactions mechanisms||proteins digestion; secondary, tertiary and quaternary structures of proteins|
|3.||Catalysis, enzymatic reactions and biocatalysis||types of catalysis; coenzymes; reactions mechanisms; biocatalytic hydrolysis||Enantio-differentiation; deracemizations; kinetic resolutions|
|4.||Nucleic acids; Lipids||DNA synthesis; reactions of fats and oils; terpenes and biosynthesis; steroids||nucleosides protecting groups; therapeutic agents|
|5.||Peptide coupling||preparation and characterization of dipeptides; structure elucidation by spectroscopy means; peptide coupling reagents; writing reports in concise manner||manipulation of chemicals; experiment design|
Instructions for students on how to achieve the learning outcomes
Students evaluation will be divided in practical and theoretical parts. The score for the theoretical part will be determined by students performance on a written exam covering the contents of the lectures. The practical component will be composed by 6 lab sessions of 2-4 h each (of mandatory attendance) and delivery of a 4 pages written report on the findings. Students performance on the lab sessions and the quality of the report will determine the score of the practical component. The final grade will be composed of 30 % from the practical component and 70 % from the theoretical component (written exam).
Numerical evaluation scale (0-5)
|Type||Name||Author||ISBN||URL||Additional information||Examination material|
|Book||Organic Chemistry||Paula Bruice||9780134042282||Part Seven , chapters 20-22, 24-26||No|
|KEB-62100 Orgaaninen kemia 1||Mandatory||1|
|KEB-64047 Organic Chemistry 2||Advisable|
1 . KEB-21001 Biokemia or previous KEB-21000 BiokemiaI
Correspondence of content
|KEB-64117 Bioorganic Chemistry, 5 cr||KEB-64116 Bioorganic Chemistry, 3 cr|