Course Catalog 2011-2012
ASE-7816 Biosensors, 5 cr
Suitable for postgraduate studies
|Study type||P1||P2||P3||P4||Summer||Implementations||Lecture times and places|
Passed exercises, laboratory work and examination.
Completion parts must belong to the same implementation
After having passed the study module the student will understand the physical operating principles of biosensors. He/she knows the basic terms and definitions. He/she understand the biology of the sensing elements and specific molecular recognition principles. The student is able to give examples of different biosensor structures and is able to understand and analyse measurement connections and amplifiers that have been used with them. The student can model and simulate the function of simple biosensors. He/she understands the limitations of the sensors. The student can list different biosensors and of their application areas.
|Content||Core content||Complementary knowledge||Specialist knowledge|
|1.||History of biosensor development, applications and requirements of biosensors.||Definition of concentrations, sampling principles|
|2.||Principles of molecular recognition, structure of enzyme and antibody, immunosensors, modeling of reactions, immobilization techniques.||Immune response, bacteria and viruses, self-assembled membranes||Molecular modeling, Langmuir-Blodgett -thin film technology|
|3.||Detection methods, electrodes, ISFET, optical sensors, Surface Plasmon Resonance (SPR) sensor, piezoelectric resonators and thermal sensors.||Principles of electrochemistry, operation principles of optical fibre sensors, modeling of SPR sensor.|
|4.||Miniaturization, biocompatibility, microanalyzers and BioMEMS structures.||Biomaterials, Micro ElectroMechanical systems (MEMS)|
|5.||Examples of commercial biosensors.|
Evaluation criteria for the course
The grade of the course is determined by examination. If the student knows the core material well, there is a possibility to pass the course with grade 3. The supplementing knowledge must be also known in order to reach a grade of 4 or 5. If in the core material there are minor shortcomings, the student will have an opportunity for the grade 1 or 2 depending on the amount of the shortcomings. Activity in exercises gives the opportunity for the additional points in the examination. If there are considerable shortcomings in the knowledge of the core material, the student will not pass the course.
Numerical evaluation scale (1-5) will be used on the course
|Type||Name||Author||ISBN||URL||Edition, availability, ...||Examination material||Language|
|Book||Biomolecular sensors||Gizeli and Lowe||0-7484-0791-X||English|
|Book||Engineering Biosensors - Kinetics and Design Applications||Ajit Sadana||0-12-613763-3||Chapters 2 & 3||English|
|Lecture slides||Biosensors||Jukka Lekkala||English|
|MIT-4010 Sensor Physics||Advisable|
|MIT-4016 Sensor Physics||Advisable|
Additional information about prerequisites
Chemistry and biochemistry studies help understanding the biological part of biosensors. The english courses are for international students.
Prerequisite relations (Requires logging in to POP)
Correspondence of content
More precise information per implementation
|Implementation||Description||Methods of instruction||Implementation|
|Introduces basic principles and techniques used in biosensors. Gives information on applications.|