KEB-64117 Bioorganic Chemistry, 5 cr

Additional information

Suitable for postgraduate studies.

Person responsible

Nuno Rafael Candeias, Alexandre Efimov

Lessons

Implementation Period Person responsible Requirements
KEB-64117 2019-01 3 Alexandre Efimov
Nuno Rafael Candeias
Attend the laboratorial sessions, prepare a short report on the lab works.
Pass the final exam based on the lectures contents and material provided.

Learning Outcomes

Understand and predict the structure and reactivity of principal organic compounds found in biological systems. Learn about the main methods used for synthetic preparation and modification of carbohydrates, amino acids and peptides, nucleic acids and the use of enzymes in asymmetric organic synthesis. The course will be composed by lectures, exercises and weekly laboratory works (2-4 h/session). Upon finalizing the lab works, students will have to prepare a 4 page report that will be used for assessment of the final grade.

Content

Content Core content Complementary knowledge Specialist knowledge
1. Carbohydrates  classification and nomenclature; reactions of monosaccharides; natural compounds from carbohydrates  anomeric effect; artificial sweeteners 
2. amino acids, peptides and proteins  synthesis and reactions of amino acids; reactions mechanisms   proteins digestion; secondary, tertiary and quaternary structures of proteins 
3. Catalysis, enzymatic reactions and biocatalysis  types of catalysis; coenzymes; reactions mechanisms; biocatalytic hydrolysis  Enantio-differentiation; deracemizations; kinetic resolutions 
4. Nucleic acids; Lipids  DNA synthesis; reactions of fats and oils; terpenes and biosynthesis; steroids  nucleosides protecting groups; therapeutic agents 
5. Peptide coupling  preparation and characterization of dipeptides; structure elucidation by spectroscopy means; peptide coupling reagents; writing reports in concise manner  manipulation of chemicals; experiment design 

Instructions for students on how to achieve the learning outcomes

Students evaluation will be divided in practical and theoretical parts. The score for the theoretical part will be determined by students performance on a written exam covering the contents of the lectures. The practical component will be composed by 6 lab sessions of 2-4 h each (of mandatory attendance) and delivery of a 4 pages written report on the findings. Students performance on the lab sessions and the quality of the report will determine the score of the practical component. The final grade will be composed of 30 % from the practical component and 70 % from the theoretical component (written exam).

Assessment scale:

Numerical evaluation scale (0-5)

Partial passing:

Completion parts must belong to the same implementation

Study material

Type Name Author ISBN URL Additional information Examination material
Book   Organic Chemistry   Paula Bruice   9780134042282     Part Seven , chapters 20-22, 24-26   No   

Prerequisites

Course Mandatory/Advisable Description
KEB-62100 Orgaaninen kemia 1 Mandatory   1
KEB-64047 Organic Chemistry 2 Advisable    

1 . KEB-21001 Biokemia or previous KEB-21000 BiokemiaI



Correspondence of content

Course Corresponds course  Description 
KEB-64117 Bioorganic Chemistry, 5 cr KEB-64116 Bioorganic Chemistry, 3 cr  

Updated by: Laine Marja-Liisa, 06.03.2019