All Publications

Alarautalahti V, Ragauskas S, Hakkarainen J, Uusitalo-Järvinen H, Uusitalo H, Hyttinen J, Kalesnykas G, Nymark S. (2019) Viability of Mouse Retinal Explant Cultures Assessed by Preservation of Functionality and Morphology. Investigative Ophthalmology & Visual Science. 60:1914-1927. doi:10.1167/iovs.18-25156

Tervonen A, Ihalainen TO, Nymark S, Hyttinen J. (2019) Structural dynamics of tight junctions modulate the properties of the epithelial barrier. PLoS ONE. 14(4):e0214876.

Korkka I, Viheriälä T, Juuti-Uusitalo K, Uusitalo-Järvinen H, Skottman H, Hyttinen J, & Nymark S. (2019) Functional Voltage-Gated Calcium Channels Are Present in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium. Stem Cells Translational Medicine. 8(2):179-193. doi: 10.1002/sctm.18-0026.

Alarautalahti V, Hiltunen M, Onnela N, Nymark S, Kellomäki M, Hyttinen J. (2018) Polypyrrole-coated electrodes show thickness-dependent stability in different conditions during 42-day follow-up in vitro. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 106(6):2202-2213. doi: 10.1002/jbm.b.34024.

Frederiksen R, Nymark S, Kolesnikov AV, Berry JD, Adler L 4th, Koutalos Y, Kefalov VJ, Cornwall MC (2016). Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods. J Gen Physiol. 2016 Jul;148(1):1-11. doi: 10.1085/jgp.201511538.

Berry J, Frederiksen R, Yao Y, Nymark S, Chen J, Cornwall C (2016). Effect of Rhodopsin Phosphorylation on Dark Adaptation in Mouse Rods. J Neurosci. 2016 Jun 29; 36(26):6973-87. doi: 10.1523/JNEUROSCI.3544-15.2016.

Ilmarinen T, Hiidenmaa H, Kööbi P, Nymark S, Sorkio A, Wang J-H, Stanzel BV, Thieltges F, Alajuuma P, Oksala O, Kataja M, Uusitalo H, and Heli Skottman (2015). Ultrathin Polyimide Membrane as Cell Carrier for Subretinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigment Epithelium. PLoS ONE. DOI: 10.1371/journal.pone.0143669. Free PMC article:

Vainio I, Abu Khamidakh A, Paci M, Skottman H, Juuti-Uusitalo K, Hyttinen J, & Nymark S. (2015) Computational Model of Ca2+ Wave Propagation in Human Retinal Pigment Epithelial ARPE-19 Cells. PLoS ONE. DOI: 10.1371/journal.pone.0128434. Free PMC article:

Ragauskas S, Leinonen H, Puranen J, Rönkkö S, Nymark S, Gurevicius K, Lipponen A, Kontkanen O, Puoliväli J, Tanila H, and Kalesnykas G. (2014) Early retinal function deficit without prominent morphological changes in the R6/2 mouse model of Huntington´s disease. PLoS ONE. DOI: 10.1371/journal.pone.0113317. Free PMC article:

Wang J-S, Nymark S, Estevez M.E, Frederiksen R, Shen S, Razafsky D, Hodzic D, Corbo J.C, Cornwall M.C, & Kefalov V.J. (2014) Chromophore supply rate-limits mammalian photoreceptor dark adaptation. Journal of Neuroscience. 34(34):11212-21. Free PMC article:

Tervonen A, Vainio I, Nymark S, Hyttinen J. (2014) Prediction of Passive Drug Permeability Across the Blood-Retinal Barrier. Pharmaceutical Research. 31(9):2297-2311. DOI 10.1007/s11095-014-1325-3.

Juuti-Uusitalo K, Delporte C, Grégoire F, Perret J, Huhtala H, Savolainen V, Nymark S, Hyttinen J, Uusitalo H, Willermain F, Skottman H. (2013) Aquaporin expression and function in human pluripotent stem cell-derived retinal pigmented epithelial cells. Investigative Ophthalmology and Visual Sciences. 54(5)3510-9.

Subrizi A, Hiidenmaa H, Ilmarinen T, Nymark S, Dubruel P, Uusitalo H, Yliperttula M, Urtti A, Skottman H. (2012) Generation of hESC-derived retinal pigment epithelium on biopolymer coated polyimide membranes. Biomaterials. 33(32):8047-54.

Nymark S*, Frederiksen R*, Woodruff ML, Cornwall MC, Fain GL. (2012) Bleaching of mouse rods: microspectrophotometry and suction-electrode recording. Journal of Physiology. 590(10):2353-64. Free PMC article:

Heikkinen H, Vinberg F, Nymark S, & Koskelainen A. (2011) Mesopic background lights enhance dark-adapted cone ERG flash responses in the intact mouse retina: a possible role for gap junctional decoupling. Journal of Neurophysiology. 105(5):2309-18. Free full text:

Haldin C*, Nymark S*, Aho A-C, Koskelainen A, & Donner K. (2009) Rod phototransduction determines the trade-off of temporal integration and speed of vision in dark-adapted toads. Journal of Neuroscience. 29: 5716-5725. Free full text:

Heikkinen H, Nymark S, Donner K., & Koskelainen A. (2009) Temperature dependence of dark-adapted sensitivity and light-adaptation in photoreceptors with A1 visual pigments: a comparison of frog L-cones and rods. Vision Research. 49: 1717-28.

Heikkinen H., Nymark S. & Koskelainen A. (2008). Mouse cone photoresponses obtained with electroretinogram from the isolated retina. Vision Research. 48(2): 264-272.

Nymark S, Haldin C, Tenhu H, & Koskelainen A. (2006). A new method for measuring free drug concentration: retinal tissue as a biosensor. Investigative  Ophthalmology and Visual Science, 47: 2583-2588.

Nymark S, Heikkinen H, Haldin C, Donner K., & Koskelainen, A. (2005). Light responses and light adaptation in rat retinal rods at different temperatures. Journal of Physiology. 567.3: 923-938. Free PMC article:

*Equal contributions