Micro- and Nanosystems - Tampere University of Technology

Micro- and Nanosystems Research Group

Professor Pasi Kallio

"The mission of our group is to develop autonomous systems for handling, treating and characterizing micro- and nanoscale  samples and objects. We combine knowledge of automation and control engineering with microsystems and nanotechnology. We develop novel functional systems in selected application areas."

The expertise areas of our group include:
- microrobotics
- microfluidics
- automation and control

We focus our research on the following application areas:
- Bio-MEMS in cell and tissue engineering
- Microrobotics for characterization of fibrous materials

You can find more information on our current active and previous projects in the different application areas after the Open Positions and Publications Sections for both Bio-MEMS and Microrobotics.

Open Positions


Publications

Publications in TUT's institutional repository

Publications (updated November 2017)

Research Activities in Cell and Tissue Engineering

In cell and tissue engineering research, our goal is to develop methods and technologies to monitor and control the direction of stem cell differentiation and influence cellular functionality using automatic control, machine learning and Bio-MEMS. We have developed concepts for mechanical stretching of cells, orientation analysis, and microfluidic perfusion, drug delivery and gas supply. See a Power Point presentation on the overview of our research activities.

Active projects
Human Spare Parts, Actuators - The project is a part of a strategic project Human Spare Parts of BioMediTech. Our objective is to develop microfluidic and microsystem technology for cultivating and stimulating cardiac (Aalto-Setälä Group), neural (Narkilahti Group), opthalmic (Skottman Group) and osteogenic (Miettinen Group) cells derived from pluripotent stem cells. We closely collaborate also with Prof. Lekkala's (sensors), Prof. Kellomäki's (biomaterials) and Prof. Hyttinen's (imaging) groups. 
 

Centre of Excellence in Body-on-Chip Research - a new CoE funded by the Academy of Finland (1.1.2018-)

WoodBone - The goal of the project is to study multi-parametric in-situ monitoring of paper fibers and osteogenic cells while they experience chemical and mechanical stimuli. The monitored parameters are internal morphological structures and their mechanical properties. We propose a microrobotic approach which does not only provide a sufficient throughput but also a possibility to respond to the changes in the measured parameters by modifying the stimulation parameters and thus, to control the material properties, for example in osteogenic differentiation.

Mini-Hypoxy - This Tekes funded TUTLi project develops technology for portable hypoxia environment and investigates its commercial potential.

MEMO - This project funded by the Academy of Finland develops microfluidic structures for epilepsy research.

Neuro TUTL - This Tekes funded TUTLi project develops technology for in vitro neuro models and investigates their commercial potential.

BioRA - The project focuses on the staff exchange between the partners of EU and China, and on the development of new technologies and applications in the field of biomedical robotics on the macro, micro and nano scales for biological cell detection, manipulation, test and injection. The project includes five participants from Europe (UK, Finland, Germany, Bulgaria) and five from China.

Previous projects

DrugPermeA - This Tekes funded project developed a novel and versatile microfluidic in vitro alternative for tissue permeability studies.

FIBAM - The project develops new methods to better understand the properties of wood derived fibers and muscle fibers in a human heart. The approach in the project is to use microrobotics, i.e automatic instruments which can precisely manipulate and measure properties of individual microscopic objects.

Stemfunc - Biomimetic Active Environment for Maturing and Differentiating Stem Cells (2008-2011)

OPTIMI - Optically Actuated Microfluidics (2007-2009)

DAAD-NANO - Nanorobot-based electrical and mechanical characterization of biological cells (2007-2009)

PICO - Development of Control Methods for Piezoelectric Actuators (2003-2008)

ACC - Automated Cell Culturing on a Well Plate (2003-2007)

LIVD - Development of Methods for Testing of Therapeutic Molecules In-vitro (2004-2006)

GENOMANDA - Automatic Manipulation, Detection and Analysis of Functions of Genes (2004-2005)

AIM - Integration of Automatic Intracellular Microinjection and Bioelectrical Recordings (2003-2004)

SOLOMANDA - Automatic Manipulation, Detection and Analysis of Individual Biological Cells (2000-2002)

 

Material characterization and microassembly

In material characterization, our approach is to develop automatic and autonomous microrobotic technologies to characterize fibrous materials at the level of individual fibers. We have developed microrobotic technologies to characterize bonding strength of pulp fibers, contact angle of liquid on a fiber, flexibility of a fiber and friction between fibers. Please have a look at our videos in http://www.youtube.com/user/ttytutase

Active projects

FibRobotics - The project studies characterization of fibre reinforced materials at micro scale using microrobotics.

WoodBone - The goal of the project is to study multi-parametric in-situ monitoring of paper fibers and osteogenic cells while they experience chemical and mechanical stimuli. The monitored parameters are internal morphological structures and their mechanical properties. We propose a microrobotic approach which does not only provide a sufficient throughput but also a possibility to respond to the changes in the measured parameters by modifying the stimulation parameters and thus, to control the material properties, for example in osteogenic differentiation.

BioRA -  The project focuses on the staff exchange between the partners of EU and China, and on the development of new technologies and applications in the field of biomedical robotics on the macro, micro and nano scales for biological cell detection, manipulation, test and injection. The project includes five participants from Europe (UK, Finland, Germany, Bulgaria) and five from China.

Previous projects

PowerBonds - The WoodWisdom-Net project aims to increase the understanding of paper strength. The strength of paper is largely dependent on the properties of individual paper fibres and inter-fibre bonds. If the strength of bonds or fibres can be improved, paper manufacturers will be able replace expensive fibres with cheaper fillers, such as chalk and clay. The project studies fibre strength and bonding capabilities using novel mechanical and chemical fibre modifications and by developing new models and characterization tools. TUT focuses on the development of microrobotic methods to automatically characrerize the stregth of individual fibre bonds.

http://www.youtube.com/user/ttytutase


FIBAM - The project develops new methods to better understand the properties of wood derived fibers and muscle fibers in a human heart. The approach in the project is to use microrobotics, i.e automatic instruments which can precisely manipulate and measure properties of individual microscopic objects.

ECNANOMAN - The project is a part of International Research Staff Exchange Programme (IRSES) in FP7. The goal is to establish a long-term research cooperation platform between Europe and China. The objective is achieved by means of staff exchange between the partners of EU and China in the areas of nano handling, assembly and manufacturing technologies. The project includes four participants from Europe (Germany, Finland, Denmark, France) and five from China.
 

FiFiBo - New Insights into Fibre-Fibre Bonding using Micro- and Nanorobotic Technologies
The goal of this researcher mobility project is to develop and deploy novel micro- and nanorobotic techniques to increase the understanding of the bonding and de-bonding of cellulose fibres. The project puts together robotic expertise in two scales: microrobotic paper fiber expertise at Tampere University of Technology and nanorobotic expertise at the University of Oldenburg.

SmartFibre - Surface Engineering of Pulp Fibres: New Functionalisation Concepts for Smart Fibre Products (2009-2011)

FPMC - Flow Process Management and Control (2006-2010)

MELA - MEMS Laminates Technologies (2003-2004)

ROBOSEM - Development of a Smart Nanorobot for Sensor-Based Handling in a Scanning Electron Microscope (2002-2004)

FEMAS - Future Electronic Microassembly Systems (2001-2002)

PAMIR - Treatment of Paper Fibers using Microsystem Technology (2000-2002)

TOMI - µASSY - Towards mini and microassembly (2000-2002)

VR-MICRO - Virtual Environment for Operation in the Micro World (1997-1999)

AMINU - Advanced Microsystems - Collaboration with Nagoya University (1999)

 

Point of Care Diagnostics and Microfluidics

Current projects

Digits - Digital Scents (2016-2017). DIGITS research project aims to develop a system prototype which measures scents by an electric nose (eNose) and digitizes them. The scents can then be reproduced by using a self-learning scent synthesiser. Our role in the project is to develop the scent synthesizer using microfluidics and machine learning methods.

Previous projects

ReDia - Ready-to-use Microfluidic Cartridges for Affordable Point-of-care Diagnostics. The objective of this collaborative Finnish-Indian project is to develop rapid tests for the detection of heart infraction and tuberculosis. ASE develops automatic microfluidic technologies for on-chip liquid handling.

nucleoTracker - Tracking Nucleic Acid Containing Compounds in Water Environment, 2010-2012
The objective of the project is to develop methods for measuring nucleic acid containing analytes in water resources. The analytes can be either biological organisms or synthetic compounds added advisedly to water. ASE develops disposable microfluidic chips for liquid handling.

NanoFlow - Enhancement of in vitro Diagnostics using Nanoparticle Labels, Nanophotonics and Microfluidics (2008-2011)

PanFlow - Microfluidics Platform for a Multi-purpose Point-of-use need System (2005-2008)

BIOAKUSTI - Microacoustic Biosensor (2006-2009)

NEOPOC - Total Analysis System for POC Diagnostics (2004-2005)

MIFLUS - Microfluidics Survey (2003-2004)

BLOSD - Development of an Automatic Blood Sampling Device (2002-2003)

FLUISY - Development of Microfluidic Systems  (1997-1999)

 

Updated by: Pasi Kallio, 20.01.2018 23:19.
Content owner: Kallio Pasi
Keywords: science and research, working at tut