The image shows human cells (U2OS) under a microscope with fluorescent nuclei (blue), mitochondria (red) and plasma membranes (green).
Researchers in the Laboratory of Biosystem Dynamics at TUT have developed software tools to automatically identify mitochondria from microscopic images to study their behaviour in live cells. Malfunctioning of the mitochondria has been associated with several age-related diseases.
The researchers explore dynamic processes, such as gene expression and aging in live cells using single-cell, single-molecule, time-lapse microscopy and state-of-the-art signal processing techniques.
The combination of novel techniques in Cell and Molecular Biology and Microscopy allows them to observe how, for example, the number, shape and position of cells and their components change over time. The results shed light on intracellular phenomena and their underlying mechanisms.
Contact information: Associate Professor Andre Ribeiro, Department of Signal Processing.